eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| scrub typhus | ||||
| Disease ID | 504 |
|---|---|
| Disease | scrub typhus |
| Definition | An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash. |
| Synonym | disease, tsutsugamushi diseases, tsutsugamushi fever, japanese river fever, tsutsugamushi fevers, tsutsugamushi japanese river fever japanese river fever (disorder) kedani fever kedani fever (disorder) mite-borne typhus mite-borne typhus due to rickettsia tsutsugamushi scrub mite-borne typhus scrub mite-borne typhus (& various types) scrub mite-borne typhus (& various types) (disorder) scrub typhus (disorder) scrub typhus (disorder) [ambiguous] scrub typhus [disease/finding] scrubs typhus tsutsugamushi tsutsugamushi dis tsutsugamushi disease tsutsugamushi disease (disorder) tsutsugamushi diseases tsutsugamushi fever tsutsugamushi fevers typhus, scrub typhus, tropical |
| Orphanet | |
| DOID | |
| UMLS | C0036472 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:39) C0036472 | tsutsugamushi | 12 C0036472 | scrub typhus | 9 C0035222 | acute respiratory distress syndrome | 7 C0041471 | typhus | 7 C1704437 | respiratory distress syndrome | 5 C0030305 | pancreatitis | 4 C0014038 | encephalitis | 4 C0008325 | cholecystitis | 3 C0025309 | meningoencephalitis | 2 C0035078 | renal failure | 2 C1145670 | respiratory failure | 2 C0022660 | acute renal failure | 2 C0271355 | abducens nerve palsy | 2 C0015230 | rash | 2 C0267841 | acalculous cholecystitis | 1 C1136085 | monoclonal gammopathy | 1 C0037998 | splenic infarction | 1 C0023890 | liver cirrhosis | 1 C0040034 | thrombocytopenia | 1 C0031154 | peritonitis | 1 C0042384 | vasculitis | 1 C0700251 | brachial plexus neuropathy | 1 C0001339 | acute pancreatitis | 1 C0025290 | aseptic meningitis | 1 C0024291 | hemophagocytic lymphohistiocytosis | 1 C0012739 | disseminated intravascular coagulation | 1 C0041466 | typhoid | 1 C0024530 | malaria | 1 C0023364 | leptospirosis | 1 C0027726 | nephrotic syndrome | 1 C0027813 | neuritis | 1 C0029089 | ophthalmoplegia | 1 C0442874 | neuropathy | 1 C0012739 | disseminated intravascular coagulation (dic) | 1 C1565489 | renal insufficiency | 1 C0024291 | hemophagocytic syndrome | 1 C0029134 | optic neuritis | 1 C0018378 | guillain-barre syndrome | 1 C0001623 | adrenal insufficiency | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:38) 2334 | AFF2 | 4.08 | DISEASES 9447 | AIM2 | 1.433 | DISEASES 157567 | ANKRD46 | 4.234 | DISEASES 545 | ATR | 1.008 | DISEASES 388372 | CCL4L1 | 1.598 | DISEASES 9560 | CCL4L2 | 1.452 | DISEASES 4345 | CD200 | 1.207 | DISEASES 959 | CD40LG | 5.492 | DISEASES 9276 | COPB2 | 3.151 | DISEASES 8454 | CUL1 | 1.496 | DISEASES 2920 | CXCL2 | 1.965 | DISEASES 1654 | DDX3X | 1.731 | DISEASES 2152 | F3 | 1.382 | DISEASES 23426 | GRIP1 | 2.313 | DISEASES 3329 | HSPD1 | 3.657 | DISEASES 5654 | HTRA1 | 3.282 | DISEASES 3620 | IDO1 | 1.223 | DISEASES 3586 | IL10 | 1.733 | DISEASES 9235 | IL32 | 1.16 | DISEASES 3710 | ITPR3 | 1.586 | DISEASES 56704 | JPH1 | 3.354 | DISEASES 57158 | JPH2 | 2.788 | DISEASES 3920 | LAMP2 | 1.061 | DISEASES 100885779 | LINC-ROR | 1.273 | DISEASES 643418 | LIPN | 2.438 | DISEASES 4050 | LTB | 1.949 | DISEASES 8031 | NCOA4 | 1.36 | DISEASES 246734 | NPCDR1 | 2.301 | DISEASES 84876 | ORAI1 | 1.504 | DISEASES 25894 | PLEKHG4 | 2.11 | DISEASES 23513 | SCRIB | 2.547 | DISEASES 6385 | SDC4 | 1.581 | DISEASES 6590 | SLPI | 1.287 | DISEASES 7099 | TLR4 | 1.155 | DISEASES 7124 | TNF | 1.872 | DISEASES 51366 | UBR5 | 1.45 | DISEASES 6375 | XCL1 | 2.515 | DISEASES 57829 | ZP4 | 2.688 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 504 |
|---|---|
| Disease | scrub typhus |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:21) C2707258 | infections C2598155 | pain C2364133 | infection C2362319 | acute respiratory distress syndrome (ards) C2029884 | hearing loss C1962971 | myocarditis C0743841 | febrile illness C0700251 | brachial plexus neuropathy C0553681 | hypofibrinogenemia C0426576 | gastrointestinal symptoms C0270627 | acute transverse myelitis C0235369 | granulomatous hepatitis C0206061 | interstitial pneumonia C0152025 | polyneuropathy C0036472 | tsutsugamushi C0035222 | acute respiratory distress syndrome C0022660 | acute renal failure C0018681 | headaches C0013456 | otalgia C0012739 | disseminated intravascular coagulation C0000727 | acute abdomen |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:12) C0036472 | tsutsugamushi | 15 C0743841 | febrile illness | 11 C0009450 | infection | 5 C0035222 | acute respiratory distress syndrome | 5 C0030193 | pain | 3 C0021311 | infections | 2 C0000727 | acute abdomen | 2 C0022660 | acute renal failure | 2 C2362319 | acute respiratory distress syndrome (ards) | 2 C0018681 | headaches | 1 C0012739 | disseminated intravascular coagulation | 1 C0700251 | brachial plexus neuropathy | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:4) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
| HP:0000083 | Renal insufficiency | MP:0003335 | exocrine pancreatic insufficiency | inadequate synthesis and/or secretion of digestive enzymes by the exocrine portion of the pancreas, usually due to loss of acinar tissue from idiopathic atrophy or acute or chronic inflammation, causing maldigestion and malabsorption of nutrients |
| HP:0002091 | Restrictive lung disease | MP:0008714 | increased lung carcinoma incidence | greater than the expected number of a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous, occurring in a specific population in a given time period |
| HP:0001892 | Abnormal bleeding | MP:0005606 | increased bleeding time | greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function |
Mapped by homologous gene(Total Items:24) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0012735 | Cough | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001250 | Seizures | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000708 | Behavioral abnormality | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0001744 | Splenomegaly | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0004372 | Reduced consciousness/confusion | MP:0013405 | increased circulating lactate level | greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase |
| HP:0002094 | Dyspnea | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0001287 | Meningitis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0001337 | Tremor | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001892 | Abnormal bleeding | MP:0020138 | delayed bone mineralization | late onset of the process by which minerals are deposited into bone |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0000975 | Hyperhidrosis | MP:0020187 | altered susceptibility to prion infection | altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is |
| HP:0002383 | Encephalitis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0000083 | Renal insufficiency | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0001254 | Lethargy | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0000613 | Photophobia | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002615 | Hypotension | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
| HP:0002716 | Lymphadenopathy | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0100758 | Gangrene | MP:0011517 | hyperoxaluria | abnormally high levels of oxalic acid or oxalates in the urine; many metal ions form insoluble precipitates with oxalate, a prominent example being calcium oxalate, the primary constituent of the most common kind of kidney stones |
| HP:0002091 | Restrictive lung disease | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0000988 | Skin rash | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| Disease ID | 504 |
|---|---|
| Disease | scrub typhus |
| Case | (Waiting for update.) |